Simon Mead Selected Research

Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease)

1/2022	Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt-Jakob disease: evaluation of a first-in-human treatment programme.
1/2021	Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion.
11/2020	Marked abnormalities of plasma protein biomarkers in Creutzfeldt-Jakob disease (CJD).
1/2020	Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic.
12/2019	Genetic Factors in Mammalian Prion Diseases.
1/2019	Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura.
1/2019	Early neurophysiological biomarkers and spinal cord pathology in inherited prion disease.
1/2018	Detection of Creutzfeldt-Jakob disease prions in skin: implications for healthcare.
1/2017	Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129.
12/2016	Diagnosing Sporadic Creutzfeldt-Jakob Disease by the Detection of Abnormal Prion Protein in Patient Urine.

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Simon Mead Research Topics

Disease

59	Prion Diseases (Transmissible Spongiform Encephalopathies) 10/2022 - 04/2003
25	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2022 - 03/2006
22	Alzheimer Disease (Alzheimer's Disease) 11/2021 - 09/2009
19	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2022 - 08/2010
18	Sporadic Creutzfeldt-Jakob Disease 01/2021 - 09/2006
15	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 12/2019 - 11/2006
14	Infections 10/2021 - 06/2006
12	Frontotemporal Dementia (Semantic Dementia) 12/2019 - 08/2011
9	Disease Progression 01/2022 - 09/2006
9	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2020 - 06/2006
8	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 05/2022 - 11/2013
8	Kuru 12/2019 - 06/2006
7	Dementia (Dementias) 10/2020 - 02/2012
4	Acquired CJD 04/2014 - 12/2007
3	Scrapie 12/2019 - 12/2007
3	Atrophy 01/2016 - 11/2010
2	Myoclonus (Nocturnal Myoclonus) 01/2022 - 01/2021
2	Tauopathies 12/2019 - 11/2013
2	Neoplasms (Cancer) 01/2019 - 11/2012
2	Brain Diseases (Brain Disorder) 04/2016 - 01/2016
2	Primary Progressive Aphasia 12/2013 - 01/2013
2	Sarcoma (Soft Tissue Sarcoma) 09/2011 - 07/2010
2	Genetic Predisposition to Disease (Genetic Predisposition) 09/2008 - 03/2006
1	Movement Disorders (Movement Disorder) 01/2022
1	Genetic Risk Score 01/2021
1	Seizures (Absence Seizure) 01/2021
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 11/2020
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 10/2020
1	Parkinson Disease (Parkinson's Disease) 10/2020
1	Death (Near-Death Experience) 01/2020
1	Chronic Wasting Disease 12/2019
1	Inflammation (Inflammations) 01/2019
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2018
1	Mitochondrial Diseases (Mitochondrial Disease) 10/2015
1	Glioma (Gliomas) 06/2015
1	Autoimmune Diseases of the Nervous System 06/2015
1	Asymptomatic Diseases 03/2015
1	Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy) 02/2015
1	Familial Amyloidosis (Hereditary Amyloidosis) 02/2015
1	Orthostatic Hypotension (Postural Hypotension) 02/2015
1	Amyloidosis 02/2015

Drug/Important Bio-Agent (IBA)

45	Prion ProteinsIBA 10/2022 - 04/2003
45	PrionsIBA 01/2022 - 06/2006
17	Codon (Codons)IBA 01/2022 - 03/2006
17	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2009
16	Biomarkers (Surrogate Marker)IBA 03/2022 - 10/2010
16	Amyloid (Amyloid Fibrils)IBA 11/2021 - 01/2011
10	ProgranulinsIBA 01/2018 - 03/2008
5	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019 - 07/2010
3	Apolipoproteins E (ApoE)IBA 01/2021 - 09/2015
3	Flavin-Adenine Dinucleotide (FAD)IBA 01/2019 - 02/2012
3	Growth Hormone (Somatotropin)IBA 01/2018 - 09/2015
3	Biological ProductsIBA 01/2018 - 01/2009
3	Methionine (L-Methionine)FDA Link 01/2016 - 11/2009
3	Valine (L-Valine)FDA Link 01/2016 - 12/2007
3	DNA (Deoxyribonucleic Acid)IBA 03/2012 - 09/2009
3	UbiquitinIBA 07/2010 - 03/2008
2	MicroRNAs (MicroRNA)IBA 03/2022 - 01/2020
2	BenzodiazepinesIBA 01/2022 - 03/2014
2	Peptides (Polypeptides)IBA 11/2021 - 01/2018
2	Presenilin-1IBA 01/2021 - 01/2013
2	LipidsIBA 09/2019 - 01/2019
2	CholesterolIBA 01/2019 - 11/2010
2	Protein Isoforms (Isoforms)IBA 12/2016 - 12/2007
2	AntibodiesIBA 06/2015 - 07/2013
2	Complement System Proteins (Complement)IBA 01/2011 - 07/2010
1	Amyloid beta-PeptidesIBA 05/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Monoclonal AntibodiesIBA 01/2022
1	Endopeptidase K (Proteinase K)IBA 01/2021
1	sharpinIBA 01/2021
1	Retinaldehyde (Retinal)IBA 11/2020
1	Blood Proteins (Serum Proteins)IBA 11/2020
1	SphingolipidsIBA 10/2020
1	tau Proteins (tau Protein)IBA 10/2020
1	Amyloidogenic ProteinsIBA 10/2020
1	Apolipoprotein E4IBA 12/2019
1	ApolipoproteinsIBA 12/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	HLA-DQA2 antigenIBA 01/2019
1	Untranslated RNA (Noncoding RNA)IBA 10/2018
1	HLA-DRB1 Chains (HLA DRB1)IBA 10/2018
1	Genetic Markers (Genetic Marker)IBA 01/2017
1	Phosphotransferases (Kinase)IBA 01/2017
1	Pharmaceutical PreparationsIBA 04/2016
1	Mitochondrial DNA (mtDNA)IBA 10/2015
1	anti-leucine-rich glioma-inactivated 1 autoantibodyIBA 06/2015
1	AntigensIBA 06/2015
1	Leucine (L-Leucine)FDA Link 06/2015
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 06/2015
1	Glycine Receptors (Glycine Receptor)IBA 06/2015
1	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 06/2015
1	Prealbumin (Transthyretin)IBA 02/2015

Therapy/Procedure

6	Therapeutics 10/2022 - 04/2013
1	Patient Transfer (Patient Dumping) 01/2020
1	Patient Care 01/2020
1	Palliative Care (Palliative Therapy) 01/2020
1	Enteral Nutrition (Feeding, Tube) 01/2019
1	Neurosurgical Procedures 01/2018
1	Transplantation 01/2018